2005•Zhongguo laonianxue zazhiRequires access
Expressions of NF-κB,IL-6 in cerebral tissue of rats with ischemic reperfusion injury
Dong Zhang
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Abstract
Objective To observe the changes of nuclear factor kappa B(NF-κB) and IL-6 in rat after cerebral ischemia-reperfusion.Methods NF-κB and IL-6 in cerebral tissue of cerebral ischemia-reperfusion model rats built by MCAO were determined by immunohistochemistry to analyze imaging.Results The level of NF-κB expression increased gradually 6 hours after reperfusion,and reached peak 1 day after reperfusion,and then gradually decreased.The site and change principle of IL-6 expression was similar to that of NF-κB except of expression peak 2 days after reperfusion,and there was significant correlation between NF-κB and IL-6(P0.01).Conclusions NF-κB and IL-6 may play an important role in inflammation pathological process of cerebral ischemia-reperfusion injury.