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2008•Prevention and Treatment of Cardio-Cerebral-Vascular DiseaseRequires access

The Changes of Nuclear Factor Kappa B(NF-κB) after Cerebral Ischemia Reperfusion in Rats

Ding Mei-pin

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Abstract

Objective To investigate the activity of NF-κB after cerebral ischemia-reperfusion in rats.Methods Cerebral ischemia-reperfusion injury was induced by 90 min of middle cerebral artery(MCA) occlusion and followed by 2h,6h,12h,24h,72h reperfusion.The infarct volume was determined by TTC stain.Level of NF-κB P65 was determined by western blot.Results The time course of NF-κB induction in brain showed that NF-κB P65 subunit obviously increased at 6h,peaked at 24h and then decreased by 72h postreperfusion.There was an increase trend in brain infarct area by time.Conclusions The level of NF-κB was increased after ischemia-reperfusion and it attenuated brain injury.

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What this paper is about

Objective To investigate the activity of NF-κB after cerebral ischemia-reperfusion in rats.Methods Cerebral ischemia-reperfusion injury was induced by 90 min of middle cerebral artery(MCA) occlusion and followed by 2h,6h,12h,24h,72h reperfusion.The infarct volume was determined by TTC stain.Level of NF-κB P65 was determined by western blot.Results The time course of NF-κB induction in brain showed that NF-κB P65 subunit obviously increased at 6h,peaked at 24h and then decreased by 72h postreperfusion.There was an increase trend in brain infarct area by time.Conclusions The level of NF-κB was increased after ischemia-reperfusion and it attenuated brain injury.

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Available abstract

Objective To investigate the activity of NF-κB after cerebral ischemia-reperfusion in rats.Methods Cerebral ischemia-reperfusion injury was induced by 90 min of middle cerebral artery(MCA) occlusion and followed by 2h,6h,12h,24h,72h reperfusion.The infarct volume was determined by TTC stain.Level of NF-κB P65 was determined by western blot.Results The time course of NF-κB induction in brain showed that NF-κB P65 subunit obviously increased at 6h,peaked at 24h and then decreased by 72h postreperfusion.There was an increase trend in brain infarct area by time.Conclusions The level of NF-κB was increased after ischemia-reperfusion and it attenuated brain injury.

Key concepts: Ischemia, Reperfusion injury, Medicine, Western blot, NF-κB, Middle cerebral artery, Anesthesia, Internal medicine

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The Changes of Nuclear Factor Kappa B(NF-κB) after Cerebral Ischemia Reperfusion in Rats — Research Paper | ScholarLens