A clinical study of treating depression with somatic symptoms by Sertraline combined with small dosage of Ziprasidone

OBJECTIVE To explore the efficacy and safety of depression with somatic symptoms by Sertraline combined with small dosage of Ziprasidone.METHODS 38 patients take Sertraline combined with small dosage of Ziprasidone are defined as the study group and 40 patients take Sertraline are defined as the control group.The time of efficacy and improvement,HAMD scores after 1,2,4,8weeks,TESS scores,compliance and the recurrence rate of depression within 1 year.RESULTS After 8 weeks treatment both groups have significant reduction in HAMD scores(P0.01).There is significant difference between two groups(P0.05).study group showed significant decrease at the first weekend(P0.05),while the control group showed significant decrease after two weeks(P0.01).Anxiety,somatization scores of HAMD got downe rapidly in the study group.The two groups showed no significant differences in TESS scores and the recurrence rate within 1year(P0.05).CONCLUSION It was indicated that the efficacy to choice of Sertraline combined with small dosage of Ziprasidone could be better than Sertraline only when treating depression with somatic symptoms.