Effect of dexmedetomidine combined with sufentanil on hemodynamics of patients undergoing laparoscopic cholecystectomy

Objective To study the effect of dexmedetomidine combined with sufentanil on hemodynamics of patients undergoing laparoscopic cholecystectomy.Methods Sixty patients undergoing laparoscopic cholecystectomy,ASA Ⅰ-Ⅱ,were randomly divided into dexmedetomidine combined with sufentanil group(composition group) and sufentanil group,30 cases in each group.Two groups were administered intravenous injection sufentanil 0.5 μg·kg-1,propofol 1.5 mg·kg-1 and vecuronium 0.15 mg·kg-1in sequence.Dexmedetomidine with 1.0 μg·kg-1 was administered intravenously within 15 minutes in composition group,synchronization induction and the same volume normal saline was given in sufentanil group in the same way.Endotracheal intubation was administrated after induction,the maintenance of anesthesia was same in the two groups.Mean arterial pressure(MAP) and heart rate(HR) were monitored and recorded at these points-before anesthesia(T0),1 minute after intubation(T1),3 minutes after pneumoperitoneum(T2),8 minutes after pneumoperitoneum(T3),18 minutes after pneumoperitoneum(T4),awaking after surgery(T5).The dosage of propofol and sufentanil were recorded.The incidence of hypertension,hypotension,tachycardia,bradycardia of two groups were recorded during pneumoperitoneum as well.Results Compared with T0,MAP significantly increased at T1-T3、T5 in sufentanil group and HR accelerated(P0.05);there were not significant differences in MAP at each point(P0.05),but the HR decelerated(P0.05)in composition group.Compared with sufentanil group,MAP and HR were significantly lower,the incidence of hypertension and tachycardia was lower,the dosage of propofol and sufentanil was less at each point in composition group(P0.05).Conclusion Dexmedetomidine with 1.0 μg·kg-1 of induction and injecting(15 minutes) sufentanil can maintain the intraoperative hemodynamics more smoothly during laparoscopic cholecystectomy.