Effects of Chaiyuwendan Decoction on ethology and monoamine neurotransmitters in brain of depressive disorder rats

Objective:To study the anti-depression mechanism of Chaiyuwendan Decoction(CYWDD).Methods:Rat models were established by separation and chronic unpredictable mild stress(CUMS).Ethology of rats were detected by open-field test and sucrose consumption test,contents of monoamine neurotransmitters were detected by HPLC-ECD.Results:Compared with normal group,the weight,the frequency of crossing,rearing and the contents of consumption to sucrosum water in depressive disorder rats decreased significantly(P0.05,P0.01),the contents of NE,DA,5-HT and HVA in amygdaloid nucleus decreased significantly(P0.05),and the contents of NE,DA and 5-HT in corpus striatum of depressive disorder rats decreased significantly(P0.05).CYWDD can improve ethology of depression rats and increase the contents of NE,5-HIAA,5-HT and HVA in amygdaloid nucleus significantly(P0.05) and increase the contents of DA significantly(P0.01)in the amygdaloid nucleus.In the corpus striatum,CYWDD can increase the contents of DA,5-HT significantly(P0.05).Conclusion:The effects of anti-depression of CYWDD may be related to the regulation of monoamine neurotransmitters in brain.