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2008•Journal of Shandong UniversityRequires access

Expressions of Cyr61,CTGF,NOV and WISP-1 in renal cell carcinoma

Jiajü Lü

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Abstract

Objective To evaluate the expressions of the CCN family members(Cyr61,CTGF,NOV and WISP-1) in human renal cell carcinoma(RCC).Methods Expressions of Cyr61,CTGF,NOV and WISP-1 were determined in 31 patients with RCC and in 18 normal kidney tissues by a semi-quantitative western blot method.Results Cyr61,CTGF,NOV and WISP-1 protein were all down-regulated in RCC.NOV or WISP-1 protein level was significantly higher in papillary RCC than that in clear cell RCC.NOV protein level was higher in G1 than G2,3 tumors(P0.01).Conclusions Down-regulation of Cyr61,CTGF,NOV and WISP-1 in RCC suggests that these CCN members might act as tumor suppressors in RCC.

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What this paper is about

Objective To evaluate the expressions of the CCN family members(Cyr61,CTGF,NOV and WISP-1) in human renal cell carcinoma(RCC).Methods Expressions of Cyr61,CTGF,NOV and WISP-1 were determined in 31 patients with RCC and in 18 normal kidney tissues by a semi-quantitative western blot method.Results Cyr61,CTGF,NOV and WISP-1 protein were all down-regulated in RCC.NOV or WISP-1 protein level was significantly higher in papillary RCC than that in clear cell RCC.NOV protein level was higher in G1 than G2,3 tumors(P0.01).Conclusions Down-regulation of Cyr61,CTGF,NOV and WISP-1 in RCC suggests that these CCN members might act as tumor suppressors in RCC.

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Available abstract

Objective To evaluate the expressions of the CCN family members(Cyr61,CTGF,NOV and WISP-1) in human renal cell carcinoma(RCC).Methods Expressions of Cyr61,CTGF,NOV and WISP-1 were determined in 31 patients with RCC and in 18 normal kidney tissues by a semi-quantitative western blot method.Results Cyr61,CTGF,NOV and WISP-1 protein were all down-regulated in RCC.NOV or WISP-1 protein level was significantly higher in papillary RCC than that in clear cell RCC.NOV protein level was higher in G1 than G2,3 tumors(P0.01).Conclusions Down-regulation of Cyr61,CTGF,NOV and WISP-1 in RCC suggests that these CCN members might act as tumor suppressors in RCC.

Key concepts: CTGF, CYR61, Renal cell carcinoma, Western blot, Cell, Pathological, Cancer research, Medicine

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Expressions of Cyr61,CTGF,NOV and WISP-1 in renal cell carcinoma — Research Paper | ScholarLens