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Expression of Wnt-induced secreted protein-1 in renal cell carcinoma

Kejia Ding

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Abstract

OBJECTIVE:To investigate the expression of Wnt-induced secreted protein-1(WISP-1)in human renal cell carcinoma(RCC)and determine whether it is correlated with RCC.METHODS:Thirty-one samples of RCC and 18 normal kidney tissues were collected.WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining.RESULTS:The media level of WISP-1 mRNA decreased significantly in tumor(3.37)compared with normal kidney tissues(9.32,P0.05).The WISP-1 mRNA median level was higher in papillary RCCs(4.67)than in clear cell RCCs(2.20,P0.05).WISP-1 mRNA expression had no relation with the stage,grade and size of RCCs.The positive rate of immunohistochemical staining was also lower in RCCs(71.0%)than in normal kidney tissues(100%,P0.05).CONCLUSION:WISP-1 may be correlated with the carcinogenesis and progression of RCC.

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OBJECTIVE:To investigate the expression of Wnt-induced secreted protein-1(WISP-1)in human renal cell carcinoma(RCC)and determine whether it is correlated with RCC.METHODS:Thirty-one samples of RCC and 18 normal kidney tissues were collected.WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining.RESULTS:The media level of WISP-1 mRNA decreased significantly in tumor(3.37)compared with normal kidney tissues(9.32,P0.05).The WISP-1 mRNA median level was higher in papillary RCCs(4.67)than in clear cell RCCs(2.20,P0.05).WISP-1 mRNA expression had no relation with the stage,grade and size of RCCs.The positive rate of immunohistochemical staining was also lower in RCCs(71.0%)than in normal kidney tissues(100%,P0.05).CONCLUSION:WISP-1 may be correlated with the carcinogenesis and progression of RCC.

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Available abstract

OBJECTIVE:To investigate the expression of Wnt-induced secreted protein-1(WISP-1)in human renal cell carcinoma(RCC)and determine whether it is correlated with RCC.METHODS:Thirty-one samples of RCC and 18 normal kidney tissues were collected.WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining.RESULTS:The media level of WISP-1 mRNA decreased significantly in tumor(3.37)compared with normal kidney tissues(9.32,P0.05).The WISP-1 mRNA median level was higher in papillary RCCs(4.67)than in clear cell RCCs(2.20,P0.05).WISP-1 mRNA expression had no relation with the stage,grade and size of RCCs.The positive rate of immunohistochemical staining was also lower in RCCs(71.0%)than in normal kidney tissues(100%,P0.05).CONCLUSION:WISP-1 may be correlated with the carcinogenesis and progression of RCC.

Key concepts: Immunohistochemistry, Renal cell carcinoma, Kidney, Messenger RNA, Pathology, Wnt signaling pathway, Staining, Carcinogenesis

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