Effects of Pulmonary Surfactants on Neonatal Respiratory Distress Syudrome

Objective To compare the efficacy and safety of pulmonary surfactants (PS) by two different administration means in treating neonatal respiratory distress syudrome (NRDS). Methods 36 neonates with NRDS were divided into 2 groups randomly, the means of administration in all patients was through tracheal tube. Neonates in one group were given curosurf in several times with different posture. Neonates in another group were given in one time with supine position. Blood gas analysis, the duration of mechanical ventilation, hours of oxygen requirement and incidence of complication before and after treatment were analyzed and compared. Results After treatment, the oxygenation and lung function of two groups improved respectively(P0.05), the differences of those index were no significant between two groups (P0.05). Conclusions Pulmonary surfactant is effective and safe for treating NRDS, and have no relationship with the means of administration.