Influence of Chongcaoyishen Granules on Expressions of α-SMA of rat Model with 5/6 Nephrectomy

Objective:To observe the protective effects of ChongCaoYiShen Granules on rat model with 5/6 nephrectomy,and explore its mechanism.Methods:Male SpragueDawley rats were randomly divided into four group:sham operation group(GroupA),model group(Group B),treatment group(Group C),control group(Group D).All rats except those from Group A reveived 5/6 nephrectomy to establish CRF model.Administration:intragastric administration were performed after the first surgery,and continued until 12 weeks after the 2nd surgery.Group A and B received 0.9% saline,Group C received water decoction of ChongCaoYiShen Granules,and Group D fosinopril sodium chloride solution once a day.Each group adopted four sampling times,0,4,8,12 weeks after 2nd surgery.10 rats in each group were sacrificed at one time to observe histomorphological changes of kidney and expressions of α-SMA.Results:ChongCaoYiShen Granules may significantly inhibit expression of α-SMA,it comparing to control group,and superior to GroupD.Conclusions:ChongCaoYiShen Granules can inhibit kidney tissue α-SMA expression,and can delay the progress of renal fibrosis.