2014•Journal of Jining Medical UniversityRequires access

The experimental study on inhibition effects of rhubarb ethanol extract on measles virus infection in vitro

LI Wen-jua

Abstract

Objective To investigate the anti-viral effects of rhubarb ethanol extract on measles virus infection in vitro.Methods Cytopathic effect(CPE)were used to evaluate the toxicity of rhubarb ethanol extract against VeroSLAM cells.The anti-viral effects of rhubarb ethanol extract on measles virus infection in vitro was observed in three experimental groups:direct effect group,anti-biosynthesis group,and precaution group.Results Rhubarb ethanol extract showed remarkable inhibitory and killing effects on measles virus.The MIC of rhubarb ethanol extract was156μg/ml while the TC0 was 5000μg/ml.So therapeutic index(TI)was 32.Conclusion It concluded that rhubarb ethanol extract showed strong antivirus effect on measles virus with high safety.

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Key concepts: Measles virus, Ethanol, In vitro, Virus, Measles, Cytopathic effect, Biology, Microbiology