The protection of glycine on the function of organ of the endotoxemia rats

Objective Toexplore the effect ofglycine(Gly) onopposing endotoxemia(LPS) and protecting organic function in burn rats.Methods Toally 24 wistar rats of either gender were randomly divided into 3 groups:simple burn group(A), sepsis group(B), Gly group(C)(n=8 each).The depilatory area was immersed into boiled water bath for above 20% TBSA partial-thickness burn injury.The rats were recovered by injecting sodium lactate ringer's fluid into the abdominal cavity(40 ml/kg)6 h later.Then, group B were injected LPS(10 mg/kg) 3 h later, and group C were given Gly(1 mg/3ml).All rats were killed , and leaving each animal's blood, liver and kidney to be determinated.Results The animal models of endotoxin were made successfully.LPS in every group was increased.Group B was dramatically higher than each other group(P0.05);the function of liver and renal was significantly abnormal in the rats with endotoxemia, however, the function was improved in group C;The general pathomorphology change of each organ showed interstitial substance inflammatory reaction after burned 12 h, and the change was significantly lessen in group C.Conclusions Gly can depress the LPS level of the sepsis rats' blood serum , and protect some organs' function.