Diagnostic significance of combined application of serum GP73 and AFP-L3 in patients with PHC

Objective To investigate the clinical significance of combined application of serum Golgi protein 73 (GP73) and alpha-fetoprotein variant (AFP-L3) in patients with primary hepatic carcinoma (PHC) . Methods Total 150 subjects were recruited,including 68 patients with PHC,42 patients with liver cirrhosis and 40 healthy controls. Serum levels of GP73 and AFP-L3 were determined by ELISA and affinity-absorbent assay,respectively. Results The critical value of GP73 was 123. 8 ? g/L. The area under curve (AUC) was 0. 909. The 95% confidence interval (CI) was 0. 835-0. 957. The sensitivity of GP73 was 72. 1% ,and the specificity was 91. 4% . The critical value was 70. 6% ,and the specificity was 93. 9% . The serum levels of GP73 and AFP-L3 in patients with PHC were significantly higher than that in patients with cirrhosis and healthy controls (P 0. 05) . Compared with single GP73 or AFP-L3,there were significant difference in the sensitivity,negative predictive value and total efficiency (P 0. 05) ,but no significant difference in specificity and positive predictive value(P 0. 05) . Conlusion The serum levels of GP73 and AFP-L3 were high in patients with PHC. At the same time,the combined application of serum GP73 and AFP-L3 can increase the diagnostic efficiency for PHC,which can be a good diagnostic marker for PHC.