Clinical Significance of Serum GP73,DCP,GPC-3 and AFP Tests in Diagnosis of Primary Hepatic Carcinoma

Objective To investigate the clinical value of serum Glogi glycoprotein 73(GP73),des-γ-carboxy prothrombin(DCP),glypican-3(GPC-3)and alpha-fetoprotein(AFP)tests for early diagnosis of primary hepatic carcinoma(PHC).Methods Totally 50 cases of PHC(PHC group),20 cases of chronic hepatitis(CH group),20 cases of liver cirrhosis(LC group),20 cases of malignant tumors of digestive system except hepatic carcinoma(DS group),and 20 cases of healthy controls(control group)were enrolled in this study.Serum GP73,DCP,and GPC-3 levels were detected using enzyme-linked immunosorbent assay.AFP was detected by electrochemiluminescence reaction.Results The serum GP73,DCP,GPC-3,and AFP levels were significantly different among these five groups.The area under curve(AUC)of GP73,DCP,GPC-3,and AFP for diagnosing the early PHC was 0.824(95%CI(0.735,0.912)),0.640(95%CI(0.533,0.746)),0.635(95%CI(0.527,0.743)),and 0.668(95%CI(0.564,0.773)).Comparison between the non-PHC group(including the CH group,LC group,DS group,and control group)and PHC group showed that GP73 had the highest sensitivity and accuracy and GPC-3 had the highest specificity.When applied in a combined manner,GP73/AFP had the highest sensitivity and accuracy.During the consequent tests,GP73,when used consequently with other tests,yielded a specificity of 100.0%.Conclusion When used alone,GP73 has superior diagnostic value than AFP for early PHC.Either DCP or GPC-3 has similar value as AFP for the differential diagnosis of early PHC.The combined GP73,DCP,GPC-3,and AFP tests has good diagnostic value for early PHC,and can be applied based on the specific clinical conditions.