The repair of rhEGF on full thickness skin wounds in mini pigs

Objective To observe the repair effects of recombinant human epidermal growth factor( rhEGF) on full thickness skin wounds in the mini pigs. Methods 48 round holes ( 12 wound / group ) of full thickness were performed on the backs of 2 pigs. They were treated repectively with rhEGF 1μg/ml, rhEGF 10μg/ml, sulfapyrimidine silver zinc cream(SDAg-Zn) and physiological saline once every other day. Results The growth of granulation tissue in all wounds were significant. The wounds treated with rhEGF were 60% filled with granulation tissue and there were a significant difference compared with the SDAg-Zn treated wounds (P 0. 05). The wounds in rhEGF group contracted-more slightly than those in SDAg-Zn group with no significant difference ( P 0. 05). And the epithelizational rates in rhEGF group were better compared with those in SDAg-Zn group and salt solution group. Conclusions The results indicated that rhEGF had positive effect in promoting the growth of granulation tissue and the epithelium growth as well as in reducing wound contraction.