Predict value of Lipoprotein (a),high-sensitivity C-reactive and their combination on coronary artery disease

Objective:To evaluate the predict value of lipoprotein(a)\[Lp(a)\],high-sensitive C-reactive protein(hs-CRP)and their combination on coronary artery stenosis in patients with coronary artery disease.Methods:A total of 580 patients underwent coronary angiography were divided into three groups:group A of 154 cases(stenosis less than 30%),group B of 243 cases(stenosis from 31 to 69%),group C of 183 cases(stenosis70%).The relationship among Lp(a),hs-CRP and severity of coronary artery disease by angiography were analyzed.Results:(1)Significant statistical differences were found between the three groups for the parameters included total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),apolipoprotein B(Apo B),Lp(a)and hs-CRP(P0.05,0.01);Compared with group B,the Lp(a)and hs-CRP significantly increased(P0.01)in group C;(2)Logistic regression analysis showed that Lp(a)and hs-CRP positively correlate with coronary artery disease(standard regression coefficient 1.415,1.329,P0.01),Lp(a)combined with hs-CRP would further elevated predicative value(P0.05).Conclusion:Lp(a)and hs-CRP levels are significant risk determinants for CAD,the predicative value of Lp(a)or hs-CRP is not better than other blood lipids,but concomitant evaluation of Lp(a)and hs-CRP may improve predicative value for CAD.