Correlation study of the ambulatory pulse pressure and the carotid remodeling in the patients with hypertension and diabetes

Objective To study the relation between the 24-hour dynamic ambulatory pulse pressure and carotid remodeling in patients with hypertension complicated with diabetes.Methods 120 patients with hypertension complicated with diabetes,100 patients with Ⅱ to Ⅲ grade of hypertension,100 patients with diabetes and 50 people as the normal control group were included the study,all the cases were received dynamic ambulatory blood pressure monitor,carotid artery intima-media thickness(IMT),the incidence of plaque,common carotid artery systolic and diastolic diameter were measured with the carotid artery ultrasound.Results The 24-hour mean pulse pressure,mean pulse pressure during the daytime,mean pulse pressure at night,carotid artery carotid atherosclerosis(IMT and plaque score)and the degree of the stiffness in the patients with hypertension and diabetes were higher than the results in the patients with hypertension and the patients with diabetes(P0.05 or P0.01).Multivariate correlation analysis showed that close correlation between carotid artery carotid atherosclerosis(IMT and plaque score)and the degree of the stiffness and the pulse pressure especially the pulse pressure at night.Conclusions Increased pulse pressure and carotid remodeling exists in patients with hypertension and patients with diabetes,but the carotid remodeling are more apparent in the patients with hypertension complicated with diabetes.The pulse pressure has a positive relation with carotid remodeling,so we should pay attention to the monitoring and curing of the pulse pressure.