Analysis on relationship between the effect of serum inflammation factors and carotid sclerosis in actue cerebral infarction

Objective To investigate the effect of serum inflammation factors and carotid sclerosis in acute cerebral infarction.Methods 95 patients with acute cerebral infarction from October 2011 to September 2012 were selected as the research group,and 38 normal people were selected as the control group.The serum interleukin 6 and high sesentive creactive protein levels in patients were observed in 24 hours and after 2 weeks.The carotid intima-media thickness and Carotid atherosclerotic plaques were also observed by Color doppler ultrasonic diagnostic instrument at the same time.Results Interleukin 6 level and high sensitivity c-reactive protein level were higher than the control group(P 0.001).The indexes of patients were lower than before after two weeks treatment,the P value of IL-6 was 0.001 and the one of hs-CRP was 0.002;The serum interleukin 6 and high sesentive c-reactive protein levels of the carotid intima-media thickness group(A group) are higher than the control group(P 0.001),the ones of the B group and C group were higher than the A group(P = 0.009),the ones of the B group were higher than C group(P = 0.040),and the differences were statistically significant;The number of the patients’carotid intima-media thickness,low echo plaques and strong echo plaques were more than the control group obviously,the ones in medium area of cerebral infarction group were more than the Lacunar cerebral infarction(P 0.001),and the differences were all statistically significant(P = 0.011).Conclusions The degree of carotid atherosclerosis and the levels of IL-6 and hs-CRP were positively related to the occurrence of cerebral infarction.