Curative effect of candesartan cilexetil in 1~2 grade essential hypertension

Aim To investigate the clinical efficacy and security of candesartan cilexetil tablets in treatment of 1～2 grade essential hypertension.Method 47 patients with 1～2 grade essential hypertension were randomly divided into the candesartan cilexetil treatment group (23 cases)and the enalapril control group (24 cases). They were respectively given candesartan cilexetil tablets 4～16 mg and enalapril maleate tablets 5～20 mg once a day,the blood pressure measured every two weeks.If the patients’diastolic blood pressure≥90mmHg,the dose would be doubled.Clinical observation had been carried out for 8 weeks.Result The blood pressures of two groups of patients were both obviously descended(P0.01).The total effective rate in candesartan group was 82.6% and that in enalapril group was 87.5%.There was no significant difference between the two groups(P0.05).The adverse effect in candesartan group obviously decreased(P0.05).Conclusion Candesartan has obviously curative effect on essential hypertension with less adverse effect.