Diltiazem vs isosorbide dinitrate in intravenous treating in patient with unstable angina pectoris

AIM:To compare the effects of dilitiazem and isosorbide dinitrate in treating patients with unstable angina pectoris. METHODS: Ninty patients with unstable angina pictoris were divided into two groups. Group dilitiazem of 42 patients (M 30, F 12; age 65 a±11 a) was given diltiazem injection 50 mg(added in 0.9% sodium chloride injection 250 mL) iv, gtt, qd×7 d. Group isosorbide dinitrate of 48 patients (M 35, F 13; age 68 a±9 a) was given isosorbide dinitrate injection 20 mg(added in 0.9% sodium chloride injection 250 mL) iv, gtt, qd×7 d. RESULTS: In group diltiazem, the total effective raties were 81% and 74%. In group isosorbide dinitrate the total effective rates were 74% and 65%. In both groups, the later rate was shown by electrocardiophy and there was no differenece. In group diltiazem, the effective rate was better than that in group isosorbide dinitrate. By 2 mo following up, nearly the same cardiovescular accidence occured in both groups. CONCLUSION: There is nearly the same therapy effectiveness both in group isosorbide dinitrate and group diltiazem, and it is more effective in patients suffered from spontaneous angina pectoris by using diltiazem.