Spectra of Clinical Pathogenic Bacterial Isolates and Their Resistance Variation in Our Hospital Infection from 2006 to 2008

Objective To investigate the distribution of clinical bacterial isolates and the change in antibiotic resistance spectrum in our hospital from 2006 to 2008. Method Data of bacterial susceptibility testing of clinical isolates from one hospital from 2006 to 2008 were collected and analyzed by software WHONET5.3,and assessed according to Clinical and Laboratory Standards Institute(CLSI) issued in 2006. Result The amount of Gram negative bacteria went down and Gram positive bacteria went up during this period.The drug resistance rate of staphylococci against penicillin and erythromycin was more than 93.0% and 53.2%,respectively.The oxacillin resistance rate of CNS was 73.8%,significantly higher than that of S.aureus 15.5%.Drug resistance rate of Enterococcus to vancomycin was 1.0%.Gram negative bacteria began to be resistant to meropenem and imipenem,whereas the resistance rate of Klebsiella and Escherichia to ampicillin was very high. Conclusion The variation of drug resistance and distribution of clinical bacterial isolates in our hospital are related to the improper use of antibiotics.It is very important to select antibiotics correctly according to the results of antibiotics susceptibility tests.