Variation of Clinical Bacterial Isolates and Antibiotic Resistance

OBJECTIVE To investigate the distribution of clinical bacterial isolates and the change in antibiotic (resistance) spectrum. METHODS A total of 5 504 strains from clinical samples in our hospital and their antibiotic (resistance) during 1998 to 2003 were studied retrospectively. RESULTS The amount of Gram-negative bacteria went down and of Gram-positive bacteria went up. Pseudomonas aeruginosa and Escherichia coli went down to 3.6% and 9.3%, coagulase-negative Staphylococcus and S. aureus went up to 35.2% and 10.6%, respectively. Drug resistance rates of Staphylococcus to vancomycin and rifampin were 0.0% and less than 46.1%, respectively. Gram-negative bacteria were poorly resistant to imipenem,piperacillin/tazobactam, amikacin (1.8-46.5%). Drug resistance rates to amphotericin B of yeasts were less than 7.7%. CONCLUSIONS The variation of drug resistance and distribution of clinical bacterial isolates are related to the improper use of antibiotics. It is very important to select antibiotics correctly according to the results of susceptibility tests.