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2011•Research and Practice on Chinese MedicinesRequires access

Determination of Matrine in Shiduqing Capsule by HPLC

Dai Long

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Abstract

Objective To establish an HPLC method for the determination of matrine in Shiduqing capsule.Methods The separation was performed on a C18 analysis column(4.6 mm×250 mm,5 μm) with acetonitrile-triethylamine(25 : 75)as the mobile phase.Flow rate was 1 mL·min-1.The wavelength was 220 nm.Results There was a good linearity within the range of 0.300 2μg~2.401 6 μg(r=0.999 9).The average recovery was 97.79%,RSD=1.69%(n=5).Conclusion This method was proved to be simple,accurate and can be used for quality control of Shiduqing Capsule.

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What this paper is about

Objective To establish an HPLC method for the determination of matrine in Shiduqing capsule.Methods The separation was performed on a C18 analysis column(4.6 mm×250 mm,5 μm) with acetonitrile-triethylamine(25 : 75)as the mobile phase.Flow rate was 1 mL·min-1.The wavelength was 220 nm.Results There was a good linearity within the range of 0.300 2μg~2.401 6 μg(r=0.999 9).The average recovery was 97.79%,RSD=1.69%(n=5).Conclusion This method was proved to be simple,accurate and can be used for quality control of Shiduqing Capsule.

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Available abstract

Objective To establish an HPLC method for the determination of matrine in Shiduqing capsule.Methods The separation was performed on a C18 analysis column(4.6 mm×250 mm,5 μm) with acetonitrile-triethylamine(25 : 75)as the mobile phase.Flow rate was 1 mL·min-1.The wavelength was 220 nm.Results There was a good linearity within the range of 0.300 2μg~2.401 6 μg(r=0.999 9).The average recovery was 97.79%,RSD=1.69%(n=5).Conclusion This method was proved to be simple,accurate and can be used for quality control of Shiduqing Capsule.

Key concepts: Matrine, Capsule, Chromatography, Triethylamine, High-performance liquid chromatography, Chemistry, Biology, Organic chemistry

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