Hemodynamic effects and anesthesia efficacy of low-dose dexmedetomidine infusion on patients with hypertension under general anesthesia

Objective To investigate the hemodynamic effect and anesthesia efficacy of low-dose dexmedeto —midine infusion on patients with hypertension under general anesthesia.Methods Sixty patients scheduled for abdomen operation under inhalational combined with intravenous anesthesia from February 2014 to January 2015 were randomly divided into two groups.Group A(n = 30) received 0.3 μg/(kg·h) of dexmedeto midine intravenously group B(n =30) received the same volume of 0.9%saline.The blood pressure,heart rate(HR),and postoperative Ramsay sedation scores and adverse reactions were recorded before injection(T_0),at 1 min before intubation(T_1),at the time point of intubation(T_2),at 1 min after intubation(T_3),at 1 min before extubation(T_4),at 1 min after extubation(T_5).Results There was no significant difference in the operation time,blood loss,extubation time,anesthesia time,recovery time and the incidence of adverse reactions between the two groups(P 0.05);In group A,the blood pressure and heart rate was significantly diminished at T_1 ~ T_5 compared with those at T_0(P 0.05);In Group B,the blood pressure and heart rate was significantly diminished at T_1 and increased at T_2 ~ T_5 compared with T_0(P 0.05).The blood pressure and heart rate in group A was lower than that of group B at T_2 ~ T_5,and the RSS score was higher at T_1 ~ T_5(P 0.05).Conclusion Low-dose dexmedetomidine infusion on patients with hypertensive during general anesthesia can provide more satisfactory sedative and analgesia effects.