2013•Journal of medical imagingRequires access
The recent therapeutic efficacy of arsenic trioxide by intravenous drip infusion during TACE perioperative combined with ~(125)I particle for the treatment of hepatocellular carcinoma
Hui Xing
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Abstract
Objective To study the recent therapeutic efficacy of arsenic trioxide by intravenous drip infusion during TACE perioperative combined with 125I particles for the treatment of hepatocellular carcinoma.Methods According to Barcelona(BCLC),67patients staging B stage of hepatocellular carcinoma were diagnosed by the clinical diagnosis.55cases were male,12cases were female,aged from 31to 77years old,with an average of 48.3years.These patients were randomly divided into two groups,A and B.There were 34cases in group A,and 33cases in group B.Arsenic trioxide by intravenous drip infusion in group A was selected,construe continued for 14days,interval of 14days.During the drop period,TACE and 125I particles therapy were given,in group B conbined TACE with 125I particles treatment were given,respectively.We evaluated its curative effect,side response,1-years of survival rate,tumor recurrence rate.Results The efficacy of group A and group B were 79.4% and 54.5% respectively.Two groups had statistical significance(P 0.05).1-years survival rate was 80.7%in group A and 75.3%in group B.Two groups had no statistical significance(P 0.05).The recurrence rate was 5.7%in the group A and 24.2%in the group B.Two groups had statistical significance(P 0.05).Two groups of patients had different degrees of nausea,vomiting,and decrease of leukocytes,alanine aminotransferase elevation,symptoms and various indicators were effectively controled after symptomatic treatment in the positive way,no serious complications and adverse reaction occurred in the two groups,two groups had no statistical significance(P 0.05).Conclusion Arsenic trioxide by intravenous drip during TACE perioperative combined with 125I particle for the treatment of hepatocellular carcinoma staging Barcelona B had good efficacy,low recurrence rate,high 1year survival rate,low poisonous deputy reaction.