2006•Jiepou kexue jinzhanRequires access

Effect of Calcitonin Gene Related Peptide and Nerve Growth Factor on the Expression of C-jun mRNA in Dorsal Thalamus of Rats with Transient Cerebral Ischemia/reperfusion

Fang Xiu-bin

Abstract

Objective To study the effect of calcitonin gene related peptide(CGRP) and nerve growth factor(NGF) on the expression of c-jun mRNA in dorsal thalamus of rats with transient cerebral ischemia/reperfusion.Methods In situ hybridization and microimage analysis were used to observe the expression of c-jun mRNA in the dorsal thalamus of rats with cerebral ischemia.Results The expression of c-jun mRNA in ischemia/reperfusion(I/R) group was increased compared with sham group(P0.01),lower in NGF group and in CGRP group than in I/R group respectively(P0.05),and markedly lower in NGF+CGRP group than in I/R group(P0.01) and in NGF group and CGRP group respectively.Conclusion CGRP and NGF downregulate the expression of c-jun mRNA and combined use of NGF and CGRP can markedly downregulate the expression of C-jun mRNA in dorsal thalamus of cerebral ischemia rats,which indicates that CGRP and NGF might have coordinate protective effects on the ischemia neurons in dorsal thalamus.

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Key concepts: Calcitonin gene-related peptide, Internal medicine, Thalamus, Endocrinology, Nerve growth factor, Ischemia, Messenger RNA, Calcitonin