Curative Efficacy of Letrozole Combined with Traditional Chinese Medicine for Ovulation Dysfunction Caused by Polycystic Ovarian Syndrome

OBJECTIVE:To evaluate the clinical efficacy and safety of letrozole combined with traditional Chinese medicine for ovulation dysfunction induced by polycystic ovarian syndrome(PCOS). METHODS: 300 PCOS outpatients were randomized to 3 groups of 100 each: clomiphene citrate (CC) group (188 cycles);urinary gonadotropin (HMG) group (104 cycles) and letrozole (LE) group (155 cycles). The occurrence rate of mature follicle,ovulation rate,pregnancy rate,abortion rate,superfoetation-terata rate,cancellation rate,incidence of no dominant follicle forming and OHSS etc were compared between the two groups after treatment. RESULTS: 30 babies were born in CC group,34 in HMG group and 43 in LE group were born. The occurrence rate of mature follicles,ovulation rate and pregnancy rate in the LE group were higher than in either CC group or HMG group(P0.05),and which were higher in HMG group than in CC group(P0.05);the abortion rate,terata rate,cancellation rate of menstruation cycles,incidence of no dominant follicle forming and OHSS were higher in LE group than in CC group or HMG group(P0.05),but the differences between CC group and HMG group were not significant(P0.05);the superfoetation rate in HMG group was higher than in CC group or LE group(P0.05). CONCLUSION: Letrozole combined with Chinese medicine can improve the ovulation rate and pregnancy rate in the treatment of infertility induced by ovulation failure in patients with PCOS;furthermore,it is economic,convenient and safe to use.