The Analysis of Therapeutic Effect of Letrozole and Clomifene Citrate in PCOS Patients

Objective: To compare letrozole with clomiphene citrate for ovulation induction treatment of polycystic ovary syndrome. Method: Review 190 polycystic ovary syndrome patients treated in Zhengzhou Central Hospital affiliated to Zhengzhou University from July 2011 to October 2013. The patients were divided into the LE group and the CC group. The ovulation rate, clinical pregnancy rate, delivery rate, early miscarriage rate, multiple pregnancy and OHSS rate were compared. Result: The ovulation rate, spontaneous abortion rate and multiple pregnancy rates between the two groups of patients were not statistically significant(P0.05). The LE group's clinical pregnancy rate was significantly higher than the CC group, the OHSS incidence was significantly lower than the CC group, and the differences between the two groups were all statistically significant(P0.05). Conclusion: LE for ovulation is closer to the body's natural cycle, compared with the traditional CC for ovulation it can effectively improve the clinical pregnancy rate, reduce the incidence of ovarian hyperstimulation syndrome. With the same ovulation effect, LE is better than CC in the prevention of spontaneous abortion and multiple pregnancy.