Clinical efficacy of intravenous infusion of amiodarone for primary atrial fibrillation acute myocardial infarction

AIM To determine the clinical efficacy of intravenous amiodarone for primary atrial fibrillation complicating acute myocardial infarction.METHODS Acute myocardial infarction patients(n = 60) with recent onset of fast atrial fibrillation were studied.After an initial intravenous infusion of amiodarone load,a continuous amiodarone infusion followed.The turning over of heart rhythm,the rate of ventricle,arterial blood pressure,Q-T interval and adverse drug reactions were observed.RESULTS After administration of amiodarone,the ventricular rates at 15 min,1 h,2 h and 24h were:(136.2±19.4),(119.4±15.9),(101.5±14.1) and(82.7±20.8) beats·min~(-1),respectively.The rates were significantly lower than the(140.3±17.5)beats·min~(-1) before the medication was given(P0.01).Atrial fibrillation reverted to sinus rhythm in 44 patients(73.3%);the arterial blood pressure and Q-T interval after amiodarone infusion remained the same(P0.05).One patient suffered sinus bradycardia.One patient experienced long RR interval but returned to normal after stopping the infusion.Phlebitis occurred in one patient.No other adverse drug reactions were observed.CONCLUSION Intravenous infusion of amiodarone is effective and safe in the treatment of fast atrial fibrillation patients with acute myocardial infarction.