Experimental study on Fructus Foeniculi and Dadix Aucklandiae against acute hepatotoxicity induced by Fructus Toosendan in rats

Objective To explore the protective effect and mechanism of Fructus Foeniculi and Dadix Aucklandiae against acute hepatotoxicity induced by Fructus Toosendan in rats.Methods SD rats were randomly divided into control group and several medicine groups.Distilled water,Fructus Toosendan(FT),Fructus Toosendan plus Fructus Foeniculi(FF),Fructus Toosendan plus Dadix Aucklandiae(FD) were given by gavage respectively.After 2 hours,the serum activities of ALT and AST were measured,and the liver/body index was calculated.The concentration of MDA and activities of SOD and GSH-Px in the hepatic tissue were determined.Results Compared with normal group,the ALT,AST,liver/body index and MDA were increased in FT group,while the SOD/MDA and activity of GSH-Px were decreased,with significant difference between the two groups(P0.05,P0.01).Compared with FT group,the ALT and AST were decreased,SOD and SOD/MDA were increased,with significant difference between the two groups(P0.05,P0.01);the MDA was decreased and SOD/MDA was increased in FD group,with significant difference(P0.01).In FF and FD groups,there were no obvious effects on liver/body index.The changes of histopatholgy were not obvious in each group.Conclusion Fructus Foeniculi and Dadix Aucklandiae can lessen the acute hepatotoxicity cause by Fructus Toosendan.The mechanisms may be related to eliminating free radicals and inhibiting peroxidation.