The Expression and Significance of CD44v6 and nm23 Proteins in Carcinoma of Gallbladder

Objetive To study the expression and significance of CD44v6 and nm23 proteins, and the relationship between the two proteins in carcinomas of gallbladder. Method 36 cases of carcinomas and 27 cases peripheral epithelium of by carcinoma in gallbladder were detected with immunohistochemistry for the expression of CD44v6 and nm23 proteins. Results The positive rates of CD44v6 and nm23 in carcinoma were 41 7% and 72 2% respectively, showing significantly higher rates than those in the peripheral epithelium of carcinoma(P0 01). There was positive relation between the expression of CD44v6 and lymphoid node metastasis(P=0 002), inverse relation between nm23 and lymphoid node metastasis and clinical stage(P was 0 003 and 0 03,respectively). There was inverse relation between CD44v6 and nm23 proteins (P=0 034). Conclusions CD44v6 and nm23 proteins may play an important role in carcinogenesis, lymphoid node metastasis and progression of carcinoma in gallbladder. They can be tumor markers to estimate the invasion and lymph node metastasis in carcinomas of gallbladder.