Antibacterial activity of moxifloxacin against clinical isolates of stenotrophomonas maltophilia

OBJECTIVE To investigate the antibacterial activity of moxifloxacin against Stenotrophomonas maltophilia and provide a theoretical basis for clinical therapy.METHODS The identification of S.maltophilia were performed by VITEK automated identification and susceptibility system equipment,the minimum inhibitory concentration of moxifloxacin and other six antibiotics to S.maltophilia were performed with standard agar dilution method.RESULTS S.maltophilia was resistant to 7 clinical antibiotics at different degree,fluctuating from 5.88% to 48.64%.Antibiotic resistance rate to cotrimoxazole was 48.64%,followed by ceftazidime,chloramphenicol and ticarcillin/clavulanic acid with the resistance rates of 28.73%,21.27% and 19.00%,respectively.The resistance rate of tigecycline derived from minocycline was 16.06%,levofloxacin showed a good antibacterial activity with the resistance rate of 6.11%,the best medicine of antimicrobial activity was moxifloxacin with the resistance rate of 5.88%.CONCLUSION Moxifloxacin shows good antibacterial activity to S.maltophilia and is suitable for clinical application.