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2011•Journal of Apoplexy and Nervous DiseasesRequires access

The experimental study of neurons protective effect of edaravone on the PD rats induced by lipopolysaccharide

Yue Huagn, Qingzan Zhao, Xiuhua Ren

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Abstract

Objective To explore the protective effect of the edaravone on dopaminergic neurons of the PD rats induced by lipopolysaccharide(LPS).Methods The rat model of PD was established after intranigral injection of 15μg LPS.Twenty-four female PD rats were randomly divided into three groups with different injection dose of edaravone(5.0mg/kg,1.0mg/kg)and the injection of saline as control.Five normal rats were set as normal group.On 28d,the number of tyrosine hydroxylase(TH)positive neurons and superoxide dismutase(SOD)and malondialdehyde(MDA)in the substantia nigra(SN)were observed.Results The TH positive neurons survived in the animals treated with edaravone were more than those of the saline group(P0.05).The SOD levers of edaravone groups was higher,while MDA level was lower than the saline group(P0.05).Conclusion Edaravone attenuates LPS-induced degeneration of rat substantia nigral dopaminergic neurons.

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Objective To explore the protective effect of the edaravone on dopaminergic neurons of the PD rats induced by lipopolysaccharide(LPS).Methods The rat model of PD was established after intranigral injection of 15μg LPS.Twenty-four female PD rats were randomly divided into three groups with different injection dose of edaravone(5.0mg/kg,1.0mg/kg)and the injection of saline as control.Five normal rats were set as normal group.On 28d,the number of tyrosine hydroxylase(TH)positive neurons and superoxide dismutase(SOD)and malondialdehyde(MDA)in the substantia nigra(SN)were observed.Results The TH positive neurons survived in the animals treated with edaravone were more than those of the saline group(P0.05).The SOD levers of edaravone groups was higher,while MDA level was lower than the saline group(P0.05).Conclusion Edaravone attenuates LPS-induced degeneration of rat substantia nigral dopaminergic neurons.

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Available abstract

Objective To explore the protective effect of the edaravone on dopaminergic neurons of the PD rats induced by lipopolysaccharide(LPS).Methods The rat model of PD was established after intranigral injection of 15μg LPS.Twenty-four female PD rats were randomly divided into three groups with different injection dose of edaravone(5.0mg/kg,1.0mg/kg)and the injection of saline as control.Five normal rats were set as normal group.On 28d,the number of tyrosine hydroxylase(TH)positive neurons and superoxide dismutase(SOD)and malondialdehyde(MDA)in the substantia nigra(SN)were observed.Results The TH positive neurons survived in the animals treated with edaravone were more than those of the saline group(P0.05).The SOD levers of edaravone groups was higher,while MDA level was lower than the saline group(P0.05).Conclusion Edaravone attenuates LPS-induced degeneration of rat substantia nigral dopaminergic neurons.

Key concepts: Edaravone, Substantia nigra, Malondialdehyde, Dopaminergic, Saline, Tyrosine hydroxylase, Lipopolysaccharide, Superoxide dismutase

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