Clinical Observation about the effect of S-1 on radio-sensitivity in conformal radio therapy of esophageal cancer

OBJECTIVE:To observe the effect of S-1 on radio-sensitivity in conformal radio therapy of esophageal cancer.METHODS: From July 2009 to November 2010,S-1 were used as radio-sensitizer combined with radiation to treat esophageal cancer.A total of 83 patients were randomized into two groups,42 patients were treated by conformal radiotherapy combined with S-1(treatment group),and 41 patients were rated by conformal radiotherapy alone(control group).RESULTS: The 1-year survival rate and lower rate for squamous cell carcinoma antigen(SCC) level in treatment group and control group were 88.1% and 70.7%(χ2=3.841,P0.05),78.6% and 58.5%(χ2=3.871,P0.05),60.0% and 25.0%(χ2=7.789,P0.05).The rate ofⅠ-Ⅱ degree bone marrow inhibition,hepatic and renal impairment and the incidence of radiation-induced esophagitis in treatment group and control group were 28.6% and 19.5%,14.2% and 4.8%,66.7% and 56.1%(P0.05).CONCLUSION: For esophageal carcinoma S-1 can improve the efficiency of conformal radiotherapy and the patients' 1-year survival rate,reduce the SCC levels in patients without a significant increase in side effects of radiotherapy.