The Association of Chronic Gastropathy with Intestinal Metaplasia Gastric Carcinoma with Helicobacter Pylori Infection

Objective To study the associations chronic gastropathy gastrice with intestinal cetaplasia carcinona with Heclicobacter pylori infection.Methods Helicobacter pylori infection was examined by warthin-starry staining in 380 cases chronic superficial gastritis、chronic atrophic gastritis、 gastric ulcer tissue and adjacent mucosa of gastric carinoma.two mucin histochemical technique,alcian blue-PH2.5-periodic–schiff(AB-PAS) and high-iron-diamine-alcian blue-PH2.5(HID-AB) were applied to differentiate the type of intestinal metaplasia with chronic superifical gastritis、chronic atrophic gastritis、gastric ulcer and adjacent mucosa of gastric carcinoma.Results Of 380 cases,the positive rate of Helicobacter pylori was 69.74%.In chronic superficial gastritis,chronic atrophic gastritis,gastric ulcer tissue and adjacent mucosa of gastric carcinoma,the positive rates of Helicobacter pylori were 73.78%,85.71%,100.00% and 80.95%,respectively.The positive rates of AB-PAS staining were 86.84%,91.43%,93.33% and 100.00%;and the positive rates of HID-AB staining were 34.21%,42.86%,53.33% and 85.7% respectively.In intestinal metaplasia of the adjacent mucosa of gastric carcinoma,incomplete colonic type accounted for 78.5% whereas in intestinal metaplasia with chronic superficial gastritis,chronic atrophic gastritis and gastric ulcer,incomplete small intestinal type accounted for 52.63%,54.28% and 53.33%,and incomplete colonic type accounted for 28.95%,31.43%,20.00%,respectively.Conclusion Helicobacter pylori infection has a close relationship with intestinal metaplasia with chronic gastropathy and gastric carcinoma;Incomplete colonic type of intestinal metaplasia in the adjacent mucosa has a close relationship with development of gasteric carcinoma;and spot incomplete colonic type of intestinal metaplasial in the tissue of chronic gastropathy has an underlying possibility to develop cancer