A Clinicopathological Study of Helicobacter Pylori Infection and Gastric Mucosal Disease

Objective To investigate the relationship between H.pylori infection and gastritis,peptic ulcer,intestinal metaplasia and gastric carcinoma.Methods Giemsa staining and AB(pH2.5)-PAS,HID-AB(pH2.5)staining were carried out to detect H.pylori in 6318 gastric mucosal biopsy specimens and to identify the subtypes of intestinal metaplasia(IM).Results H.pylori infection rate were 73.90%,69.74%,80.95%,62.12% in groups of chronic superficial gastritis,atrophic gastritis,duodenal and gastric ulcer,gastric carcinoma respectively.Compared with normal mucosa group,these differences were highly statistically significant( P 0.001).The infection rate in IM group was significantly different from that in the normal mucosa group( P 0.001).But no significant differences were observed among the four subtypes of IM( P 0.05).The infection rate in intestinal type carcinoma group was not significantly different from that in diffusing type carcinoma( P 0.05).Conclusion It seems that H.pylori infection correlates higly with gastritis,peptic ulcer,intestinal metaplasia and gastric carcinoma.