Risk factors of the perioperative liver failure after hepatectomy

Objective To investigate the risk factors of the perioperative liver failure after hepatectomy and to find the strategy to avoid it.Methods Clinical and pathological data of 486 cases of patients with hepatic cell carcinoma were collected.The perioperative risk factors in the patients with the complication were analyzed.Results Among 486 patients with hepatectomy,74 patients(15.23%) occurred 1iver failure.The patients were divided into liver failure group and non-failure group based on whether postoperative liver failure,clinical data were analyzed in two groups,and serum interleukin-6(IL-6) and tumor necrosis factor(TNF-α) changes before and after 24 hours were measured and analyzed by enzyme-linked immunosorbent assay(ELISA).The related regression analysis for liver failure revealed that the pa tients occurring complications after hepatectomy were significantly related to patients with Child-Pugh classification,blood loss(P0.05).The serum IL-6 and TNF-α of liver failure group were higher than those in non-failure group at preoperative and 24 h after operation.The serum IL-6 and TNF-α of 24 h after operation were higher than those in preoperative in two groups.The differences were significant(P0.05).Conclusion It is important that positive liver protection therapy and less bleeding for reducing the occurrence of liver failure after hepatectomy.Related inflammation factors can be used to the assessment and diagnose of liver failure.