2012•Unpublished venueRequires access
The expression and clinical significance of E2F3 in laryngeal squamous cell carcinoma
Fuhui Huang
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Abstract
Objective:To study the expression and clinical significance of E2F3 in laryngeal squamous cell carcinoma.Methods:Immunohistochemical staining was used to detect the expression of E2F3 protein in 136 laryngeal squamous cell carcinoma tissues and 79 adjacent normal tissues.The correlations of E2F3 with clinicopathological factors were analyzed.Results:The positive rates of E2F3 in the adjacent normal tissues and laryngeal squamous cell carcinoma tissues were 90.44%(123/136) and 27.85%(22/79) respectively.The expression of E2F3 in laryngeal squamous cell carcinoma was higher than that in normal mucosa(P0.01).The expression of E2F3 in laryngeal squamous cell carcinoma tissues was correlated with the clinical stage,age,type,and differentiation degree(P0.05).And it was not correlated with the T stage,lymph node metastasis,smoking and gender(P0.05).In addition,very high level expression of nuclear E2F3 was found in almost all subglottic laryngeal squamous cell carcinomas.Conclusion:The expression of E2F3 was highly up-regulated in laryngeal squamous cell carcinoma tissue.It had a relationship with the clinical stage,age,type,and differentiation degree.It may have an important significance on predicting the invasion of laryngeal squamous cell carcinomas,and may permit the laryngeal tumorigenesis and progression.