Adjustment Effects of Seed Oil of Punica gramatum L. on Blood-lipid and Lipid-Hyperoxidation in Hyperlipidemia Rats

Objective: To study the adjustment effects of seed oil of Punica gramatum L. on blood-lipid and lipid-hyperoxidation in hyperlipidemia rats. Method: 50 female Wistar rats were divided randomly into 5 groups by body weight: control group, hyperlipidemia model group, seed oil of Punica gramatum L. high and low dose group and simvastatin group. The rats were fed with high-lipid foodstuff except control group, so the intervention tests were carried out. Results: After twelve weeks, the contents of serum and hepar total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), arteriosclerosis index (AI) and malondialdehyde(MDA) of hyperlipidemia model group were all higher than the control group (p0.05 or p0.01), but high density lipoprotein ratio to total cholesterol (HDL-C/TC) and superoxide dismutase (SOD) activities were lower than the control group(p0.05 or p0.01). The contents of serum and hepar total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), arteriosclerosis index(AI), malondialdehyde(MDA) in Punica gramatum L. low dose seed oil group were all lower than the hyperlipidemia model group (p0.05 or p0.01), but the high density lipoprotein ratio total cholesterol (HDL-C/TC) and superoxide dismutase(SOD) activities were higher than the control hyperlipidemia model group (p0.05 or p0.01). Conclusion: Seed oil of Punica gramatum L. has significant effects on controlling hyperlipidemia and atherosclerosisi n rats.