PHARMACOKINETICS AND BIOAVAILABILITY OF LEHMANNINE IN RABBITS

In rabbits,having a dose of 40 mg/kg of lehmannine the drugconcentration-time curves fitted two compartment open model after iv administra-tion,one compartment open model after im and po administration,respectively.The principal pharmacokinetic parameters of iv administration were as follows:C_0=28.34μg/ml,α=0.077 min~(-1),β=0.016min~(-1);V=2040.73 ml/kg,Cl=32.65 ml/(min·kg),AUC=1225.1μg·min/(ml·kg).