Preparation of 4-Aminobenzyl Alcohol by Hydrazine Hydrate Reduction Method in the Presence of Pd/C Catalyst
Wei Chang-mei
Abstract
Wei Chang-mei
Abstract
4-Nitrobenzyl alcohol(3.83 g) was reduced by hydrazine hydrate(2.94 g) for 3.5 h at 80~85 ℃ in the presence of Pd/C catalyst(0.60 g).The crude product was recrystallized from ethanol and water to give 2.788 g 4-aminobenzyl alcohol(90.67% yield).The average yield of three decuple enlargement experiments was 88.56%.
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4-Nitrobenzyl alcohol(3.83 g) was reduced by hydrazine hydrate(2.94 g) for 3.5 h at 80~85 ℃ in the presence of Pd/C catalyst(0.60 g).The crude product was recrystallized from ethanol and water to give 2.788 g 4-aminobenzyl alcohol(90.67% yield).The average yield of three decuple enlargement experiments was 88.56%.
Key concepts: Hydrazine (antidepressant), Hydrate, Alcohol, Yield (engineering), Catalysis, Ethanol, Chemistry, Nuclear chemistry