Effect of taurine on retina in rats with the damage of retinal ischemia-reperfusion

Objective To investigate the effect of taurine on retina in rats with the damage of retinal ischemia-reperfusion and its mechanism.Methods 120 Wistar rats were divided randomly into 3 groups: control group,ischemia group,protective group.Increasing the intraocular pressure to 110 mm Hg for 60 minutes with anterior chambers infused liquid induced the models of retinal ischemia-reperfusion of rats,3 days,30 minutes before retinal ischemia,the rats in the protective group received a intraperitoneal injection of taurine at dose of 100 mg/kg twice a day for 3 days and the rats in the control group received a intraperitoneal injection of sodium chloride at same dose,at 30 minutes,12 hours,24 hours,48 hours,72 hours after ischemia-reperfusion,the effect of taurine on retinal degeneration was assessed by measuring the level of SOD,MDA,NO and the thickness of the inner retinal layers(MTIRL).Results The level of SOD was decreased,but those of MDA and NO both were increased after ischemia-reperfusion retina of rats.the changes of MDA and NO were blocked by taurine.but the effect of taurine to SOD was not confirmed.Conclusion Taurine can protect the retine from ischemia-reperfusion injury.