Therapeutic Effect of Lentinan in Combination With Adefovir Dipivoxil on Liver Fibrosis in Chronic Hepatitis B Patients

Objective To observe the influence of lentinan(LET) in combination with adefovir dipivoxil(ADV) on liver fibrosis indexes in hepatitis B e antigen positive adults with chronic hepatitis B. Methods Patients with chronic hepatitis B were randomly assigned to receive the treatment with adefovir or adefovir plus lentinan for a minimum of six months.The parameters,including diameter of portal vein and splenic vein(Dpv and Dsv),speed of blood flow in portal vein(Spv) as well as liver fibrosis indexes,such as hyaluronic acid(HA),the procollagen type Ⅲ N-terminal propeptide(PⅢNP),type Ⅳ collagen(Ⅳ-C) and laminin(LN),were determined before and after treatment. Results The above mentioned parameters in the post-treatment was improved,compared with in the pro-treatment.Furthermore,after treatment the improvement in combination group was significantly superior to that in the ADV monotherapy group,especially the makers of HA,PⅢNP,Ⅳ-C,LN and Spv. Conclusions Adefovir dipivoxil could improve the liver fibrosis in the chronic hepatitis B.Lentinan could efficiently enhance the anti-fibrotic effect of ADV on liver fibrosis of chronic hepatitis B patients.