A clinical control study of Paliperidone and Ziprasidone in schizophrenia

Objective:To compare the efficacy and safety of Paliperidone and Ziprasidone I n the treatment of Schizophrenia.Methods:86 patients with schizophrenia by CCMD-3 were randomly into two groups treated with Paliperidone or Ziprasidone for 8 weeks..The ratio of the reduction of Positive and Negative Symptom Scale(PANSS) was used to assess efficacy,and Personal and Social Performance Scale(PSP) was used to assess social function,while the treatment emergent symptom scale(TESS) was used to assess side effects.Results: In the end of curing,the two groups showed no statistical difference in the efficacy rate,the scores of PANSS,and the adverse effect(P0.05).There was statistical significance in the scores of PSP for the two groups(P0.001).Conclusions: Both Paliperidone and Ziprasidone are effective and few adverse effect for patients with schizophrenia.The Paliperidone is more effective than the Ziprasidone in terms of improving Personal and Social Performance Scale.