Evaluation of intravenous moxifloxacin in the treatment of lower respiratory tract infection

ObjectiveTo compare the efficacy and tolerability of moxifloxacin and levofloxacin in treating lower respiratory tract infections. MethodsAn open-label,randomized,levofloxacin controlled and non-controlled study was conducted.The treatment group(including controlled part and all patients of non-controlled part) were given moxifloxacin 400 mg,intravenous infusion,once daily.The patients in control group were treated with levofloxacin 200 mg intravenous infusion,bid.All patients were treated for 7-14 days. ResultsSeven days after end of treatment,the overall clinical cure rate and effective rate of moxifloxacin group were 33.3% and 81.9%(38.7% and 87.1% in controlled part;34.1% and 78.0% in non-controlled part).The corresponding rates were 43.3% and 86.7% in levofloxacin group.The bacterial eradication rate of all the three groups was 100%.The incidence of drug-related adverse reaction was 14.9% and 18.8% for moxifloxacin and levofloxacin respectively. ConclusionsOnce daily moxifloxacin intravenous infusion is as effective and safe as intravenous treatment with levofloxacin twice-daily.