2004•Chinese Journal of Clinical Oncology and RehabilitationRequires access
Relation between expression of MMP-2 and MMP-9 and invasion, metastasis of epithelial caranoma of ovary
Xiaoyan Wang
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Abstract
Objective To study the expression of matrix metalloproteinases (MMP-2, MMP-9) in epithelial carcinoma of the ovary and to explore their relation to invasion, metastasis and prognosis. Methods The expression of MMP-2,MMP-9 in 47 epithelial ovarian carcinomas was investigated by the immunohistochemical method. Results There were no significant differences in the expression of MMP-2 and MMP-9 between different histologi-cal types of ovarian carcinomas, but significant difference in MMP-2, MMP-9 expression was found between different clinical stages,primary and relapse,different histological grades.There was negative correlation between the expression of MMP-2, MMP-9 and survival time. Conclusion The expression of MMP-2 and MMP-9 correlated with invasion, metastasis and prognosis of epithelial ovarian carcinomas.