CHINET 2009 surveillance of antimicrobial resistance in Pseudomonas aeruginosa in China

Objective To investigate the antimicrobial resistance of P.aeruginosa in China during 2009.Methods Clinical isolates of P.aeruginosa were collected from 14 teaching hospitals in China.Antimicrobial susceptibility was tested by Kirby-Bauer method.The data were analyzed by WHONET 5.4 software.Results Of the 4 912 clinical P.aeruginosa isolates,91.9% strains were isolated from hospitalized patients,and 73.6% were isolated from respiratory tract.The isolates showed the lowest resistance rate(14.8%)to amikacin.The resistance rates to other antimicrobial agents were above 18%.The resistance rates of the P.aeruginosa strains from Kunming Hospital were higher than 30% to most antibiotics,except cefoperazone-sulbactam,cefotaxime,cefoperazone and piperacillin-tazobactam.For the strains from Shanghai Pediatric Hospital,the resistance rate was less than 10% to each antimicrobial agent.The pan-resistant P.aeruginosa strains(only sensitive to colistin)accounted for 1.7%.Conclusions The antimicrobial resistance of P.aeruginosa is still a serious problem in China.The antimicrobial susceptibility pattern varied in different hospitals.ICU is still the focus of antibiotic resistance monitoring.The surveillance of antimicrobial resistance is very important for rational antimicrobial therapy.