CHINET 2010 surveillance of antimicrobial resistance in Pseudomonas aeruginosa

Objective To investigate the antimicrobial resistance of P.aeruginosa in China during 2010.Methods Clinical isolates of P.aeruginosa were collected from 14 teaching hospitals in China.The antimicrobial susceptibility were tested by Kirby-Bauer method and MIC determination.The data were analyzed by WHONET 5.4 software.Results Of the 5 080 clinical strains of P.aeruginosa,91.2% were isolated from hospitalized patients,and 69.9% were isolated from respiratory tract.These P.aeruginosa isolates showed the lowest resistance rate(15.3%) to amikacin.The percentage of the P.aeruginosa isolates resistant to other antimicrobial agents was generally above 18%.The P.aeruginosa strains collected from Kunming Hospital showed the highest resistance rate to 13 of the 14 antimicrobial agents compared with the strains from other hospitals.More than 28% of the isolates from Kunming Hospital were resistant to any of the antimicrobial agents tested.More than 40% of the strains isolated from a Beijing hospital were resistant to most of the antimicrobial agents tested.The isolates collected from a hospital in Gansu Province were less resistant(20%) to any of the antibiotics except cefoperazone and aztreonam.For the strains from Shanghai Children's Hospital,the resistance rate to any of the antimicrobial agents was lower than 5%.The resistance of P.aeruginosa strains from ICU was significantly higher than the resistance of the strains as a whole.The panresistant(only sensitive to colistin) P.aeruginosa strains accounted for 1.7% on average.Conclusions The antimicrobial resistance of P.aeruginosa is still a serious problem in China,but shows slight downward trend.The antimicrobial susceptibility pattern varied greatly with the hospital,and geographical region.ICUs are the focus of interest for resistance monitoring and control.The surveillance of antimicrobial resistance is very important for guiding rational antimicrobial therapy in healthcare facilities.