Relationship Between Levels of Serum MMP-9,TIMP-1 and Acute Stage of Cerebral Infarction

Objective To study the relationship among the levels of serum MMP-9,TIMP-1 and the classification of TOAST and the significance in prognosis in patients with cerebral infarction. Methods Ninety patients with cerebral infarction were included in our study,while 30 healthy people served as the control group.According to TOAST,the patients were divided into three subtypes: CE,LAA,and SA.The serum specimens were gathered for MMP-9 and TIMP-1 determination with ELISA on admission,at the 7th and 14th days of onset.All patients were recorded Barthal index(BI) on the first month of onset. Results The serum level of MMP-9 increased after cerebral infarction,and were significantly higher than that in the control group(P0.05).MMP-9 in CE and LAA groups was significantly higher than that in SA group(P0.05).At the 14th day MMP-9 in all groups decreased to normal.The serum level of TIMP-1 increased after cerebral infarction,and were significantly higher than that in the control group(P0.05).TIMP-1 in CE and LAA groups were significantly higher than that in SA group(P0.05).At the 14th day TIMP-1 in all groups decreased to normal. The serum level of MMP-9 in the patients with better prognosis(567.1±263.0 ng/ml) was significantly lower than that in the patients with poor prognosis(893.7±451.1 ng/ml),there was a statistically significant difference between them(P0.05). Conclusions The level of serum MMP-9 within 24 hours of onset can reflect the classification,and also can use as an independent indicator of prognosis.