THE INTERVENTION OF SELENIUM ON THE OXIDATIVE DAMAGE BY IODINE EXCESS IN MICE

Objective:To study the mechanism of goiter resulted from excess of iodine and seek suitable selenium intervention dosage. Method:One hundred and forty Balb/c mice were divided into seven groups: the normal control group, the high iodine group (drinking the water containing iodine 3 000μg/L) and five selenium groups (drinking the water containing iodine 3 000 μg/L and selenium 0.1, 0.2, 0.3, 0.4, 0.5mg/L). The GSH-Px、SOD activities and the concentration of MDA in plasma, liver and kidney were determined. Result:The GSH-Px、SOD activities of high-iodine group decreased significantly and MDA increased significantly compared with normal control group. There was no difference between normal control group and the groups drinking the water containing 0.2-0.3 mg/L selenium. Conclusion:Iodine excess results in oxidative damage and 0.2-0.3 mg/L selenium is an effective intervention dosage.