An Effective Analysis of Two Combination Chemotherapy Plans in Treating MDR-PTB

Objective To contrast the efficacy of the two combination chemotherapy plans with LVFX,AMK in the treatment of mul--drug resistant pulmonary tuberculosis[MDR-PTB].Methods 162 cases of these patients were divided into study group and control group according to different degree of drug resistance.84 cases were in the study group,its plan included mainly LVFX and AMK in combination with RFE,PAS,PZA and EMB.78 cases was in the control group,its plan mainly included OVFX,AMK in combination with INH,RFP,PZA and EMB.Results At the end of the treatment courses,the sputum negative conversion rate of the study group was respectively 85.7%;the radiographic improvement rate was 50.0%.The clusure rate was 62.3%.Accordingly,the sputum negative conversion rate of control group was respectively 59.0%,the radiographic improvement rate was 26.9%,the clusure rate was 39.7%.There was marked difference between the study group and the control group(P0.01).The occurrence rate of drug side-effects in the study group was 22.6%;in the control group it was 26.9%.The difference between the study group and control group was not significant(P0.05).The recurrence rates of study group was 2.8%;the control group was 22.5%.The difference between study group and control group was prominent(P0.01).Conclusion The study group treatment plans could enhance sputum negative conversion rates and lower their recurrence rates,which were safe,dependable,and worth popularizing.